What Is the Sinclair Method for Alcohol Addiction?

Last Updated on September 23, 2021

If you’re struggling to drink “normally,” but don’t want to quit drinking altogether, you should know that abstinence isn’t the only option. There’s also the Sinclair Method.

The Sinclair Method can significantly reduce your drinking without requiring you to quit cold turkey. Although the treatment hasn’t gained much traction in the U.S. yet, it’s affordable, can be done at home and—most importantly—it works. First developed in Finland, it is an accepted form of treatment there and in the U.K.1—and it’s slowly catching on with U.S. doctors2 as well.

In this post, you’ll learn about what the Sinclair Method is and why it works so well for alcohol addiction and overdrinking.

What Is the Sinclair Method?

Sinclair Method for alcohol addiction naltrexone pill
With the Sinclair Method, all you need to do is take one dose of naltrexone one hour before you drink. Image by rawpixel on Unsplash

The Sinclair Method, or TSM, is a treatment to reduce or stop drinking by taking craving-reducing medication in a specific way. Abstinence-based treatments, such as Alcoholics Anonymous (AA), ask you to stop drinking as soon as you start the program. TSM, however, realizes quitting cold turkey is difficult for many people, so it encourages them to drink while they’re taking their anti-craving medication. Although this may sound counter-intuitive, here’s the result: The medication blocks the brain’s alcohol “reward” signal, reducing the motivation to drink.

When following this method, doctors typically prescribe naltrexone. However, not every doctor tells their patients to take naltrexone in the same way. For example, some doctors encourage patients to quit drinking before they start taking the drug. TSM is different. You can still drink while taking naltrexone. It may not reduce drinking immediately, but eventually, you may notice that you can stop after just one or two drinks. Some people end up quitting alcohol altogether.

As one recent study found3, medication for alcohol abuse and dependency is severely under-prescribed by doctors—even though there’s plenty of research to support its effectiveness.

In a series of clinical trials4, Dr. John David Sinclair—who developed the Sinclair Method— found that naltrexone didn’t help if the patient was told to remain abstinent. However, if the medication was paired with drinking—specifically, if naltrexone was taken one hour before the start of a drinking session—it was effective and safe. And while the strict terms of TSM are still up for debate in the scientific community (some doctors find the medication to be more effective when taken at the same time every day instead of one hour before drinking), it is generally agreed that naltrexone significantly reduces5 heavy drinking, cravings, and relapse episodes6.

How Does the Sinclair Method Help Alcohol Addiction?

Before we go over how TSM helps, we should ask: How does alcohol dependence manifest in the first place?

Sinclair Method alcohol brain
The Sinclair Method works by severing the link between alcohol and pleasure. Image by GDJ on Pixabay

Your brain releases endorphins when you drink, and endorphins make you feel good. Over time, your brain remembers this, and may start to connect alcohol with pleasure. You may start to drink to get that same euphoric feeling. Even if you know it’s not healthy, it’s hard to stop because the craving now seems uncontrollable.

If the problem is a connection between pleasure and alcohol, then we need to break that connection. One way of breaking it is by using a medication to block endorphins when we drink. That’s what naltrexone does. With endorphins blocked, you don’t experience the same satisfaction from drinking alcohol; it begins to feel less rewarding.

It’s important to note that a person can still get drunk when taking naltrexone following TSM, and drinking can still provide some enjoyment. But over time, as you have more and more drinking sessions on naltrexone, where the rewards from alcohol are blocked and therefore not reinforced, you start to care less about drinking.

Interested in trying TSM? Here’s what you can generally expect:

  • Meet with a knowledgeable physician to discuss your drinking history and goals
  • Once the medication is prescribed, take it at least one hour before you start drinking
  • Drink as you normally would (Note: Although medication blocks the endorphins or the “reward” your brain feels from drinking, it doesn’t take away the effects of being drunk)
  • Continue taking medication before drinking (as directed by your physician)
  • Combine with counseling/coaching to increase the short and long-term effectiveness of treatment
  • Track your consumption to watch it decline over weeks, months, and years

While naltrexone can help you reduce cravings, there may be other areas you need to tackle before you can fully mend your relationship with alcohol. These include:

  • Triggers
  • Underlying causes
  • Healthy ways to cope
  • Communicating drinking changes with family and friends

Because these issues sometimes can’t be addressed by medication alone, counseling is recommended. At Ria Health, we prescribe anti-craving medication, but we also assign you a personal recovery coach. Your coach can teach you techniques, track your progress, provide encouragement, and walk you through setbacks.

Will the Sinclair Method Work for Me?

If you’re thinking about trying the Sinclair Method, here’s what you should consider.

The Sinclair Method may be right for you if:

The Sinclair Method can help you regain control over alcohol
Image by Dvir Adler on Unsplash
  • You have cravings for alcohol
  • You’re motivated to change your habits
  • You want to drink less or not at all
  • You have a healthy liver
  • Some research shows that naltrexone may be more effective7 if you have a family history of alcohol dependence

The Sinclair Method may not be right for you if:

  • You want to quit cold turkey or are strictly looking for abstinence-based approaches
  • You want an immediate solution (you’ll need to have patience through the process)
  • You’re taking an opioid-based medication, or any drugs that interact with naltrexone (in this case, another anti-craving medication like baclofen or gabapentin may be prescribed)
  • You struggle with self-motivation to take the medication or monitor your progress
  • You’re part of the 10 percent of people for whom naltrexone’s normally mild side effects are too severe (again, there are other medications you can take)

Whether to you’d like to drink less or stop completely, your goals are in reach! Start our at-home program today to begin seeing results.

Riannon Westall is a health writer based in Toronto, Canada. Her work has been featured in the Toronto Star, on CBC.ca and on various blogs. She writes articles and website copy that further her clients’ goal of helping people create healthier and more fulfilling lives.


Medically reviewed by:
Chief Medical Officer
Dr. John Mendelson is a Board Certified Internist with over 30 years of research and practice.
Riannon Westall
Written By:
Toronto-based health writer. Background in newsroom journalism, content marketing, and research.
Edited by:
Content Writer/Editor
Writer specializing in targeted, informative content. Dedicated to making the abstract accessible.

2 thoughts on “What Is the Sinclair Method for Alcohol Addiction?

  1. Pingback: Who is Considered an Alcoholic? Alcoholism Facts You Should Know – Miss Frugal Mommy

  2. Mark says:

    You are doing amazing work! Thanks for sharing your wonderful posts. Naltrexone is seriously amazing, I will always remember the day I took it, I had a moment of realisation that the craving had gone, the constant battle in my head had stopped. So happy 😊 I found ‘NLTRX247’ in Google and got the treatment. I was a heavy habitual binge drinker. The only thing I would say is you have to want to quit drinking or there is no point, take it daily. I’ve been around alcohol, parties, bars and I just don’t want it. It’s brilliant 👍!!

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